Monday, December 11, 2017

Paraneoplastic Syndromes

Lung Cancer
1. Small Cell Carcinoma

  • SIADH - excess ADH --> hyponatremia
  • Cushing Syndrome - excess ACTH
  • Lambert-Eaton - antibodies against presynaptic Ca2+ channels --> prevents release of Ach


2. Squamous Cell Carcinoma

  • Hypercalcemia - PTHrP, "stones, bones, groans, psychiatric overtones"


Kidney Cancer
1. Renal Cell Carcinoma

  • Cushing Syndrome - excess ACTH
  • Polycythemia - excess EPO
  • HTN - excess renin
  • Hypercalcemia - PTHrP, "stones, bones, groans, psychiatric overtones"

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