Wednesday, February 8, 2017

Neuromuscular Nicotinic Receptor Blockers

Succinylcholine
  • Metabolized by plasma cholinesterase
  • Apnea
  • Hyperthermia
  • Bradycardia
  • Histamine
Benzylisoquinoline
  • Non-hepatic metabolism 
1. Atracurium
  • Laudanosine accumulates and causes seizures
2. Cisatracurium
  • Cis isomer
  • Does not accumulate

Aminosteriods
  • Hepatic and renal metabolism 
1. Pancuronium/Doxacurium/Pipecuronium
  • Difficult to achieve reversal
2. Rocuronium
  • Less potent so anesthesia for intubation
  • Hypersensitivity

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