Lipophilic
GABA receptor
Local Anesthesia
Bind to Na+ channels during refractory period
High firing nerves more susceptible
Weak bases
Ionized once inside cell so it can bind to receptor
Pain-->temperature-->touch-->pressure
Adverse effects: cardiotoxicity and seizures
Epinephrine can be used as "adjunctive" to prolong the effects of other local anesthesia
No comments:
Post a Comment